For greater than a century, scientists have observed water has quite a lot of uncommon properties that don’t match throughout the basic mannequin of it being only a strong, liquid or gasoline.
Gerald Pollack constructed upon these observations, and ultimately decided that when a negatively charged floor is current, if an applicable vitality supply can also be current (notably infrared — which is all over the place), the water will assemble itself into layers of offset hexagonal sheets with the method H3O2 that behave like a liquid crystal.
Word: Along with gentle, sound can even generate H3O2.
In my eyes, liquid crystalline water is a critically beneath appreciated space of science because it supplies a mechanism to elucidate most of the unexplained mysteries of the physique (e.g., how achieve this many fluids circulate inside it regardless of there being no recognized pump to maneuver them) and a solution to put phrases into a lot of what we regularly observe throughout the physique.
What Is Liquid Crystalline Water?
Liquid crystalline water has a big diploma of solidity, and can expel most issues from coming into it (e.g., polystyrene microspheres), together with the displaced hydrogen atoms (as it’s H1.5O not H2O). These displaced positively charged H atoms (henceforth known as protons), in flip assemble instantly exterior this lattice, thereby making a pH and cost gradient which may be measured.
In lots of instances, these H3O2 lattices may be huge — in favorable situations, Pollack and others have measured ones starting from 0.1 millimeters to 0.5 millimeters (100,000 to 500,000 nanometers or nm) in measurement. Cells rely on this water, so that they include a lot of surfaces from which the water can type.
For instance, 20% of the cell is occupied by its cytoskeleton (a protein lattice which maintains its construction), and evaluation of high-voltage electron micrographs have proven that throughout the cytoskeleton, over half of the water current is inside 5 nm of a floor it might probably type H3O2 on (for reference a single H2O molecule is 0.27 nm in measurement).
For the reason that floor websites that water can construction on are so intently packed collectively in cells, it’s comprehensible why liquid crystalline water (additionally generally referred to as EZ water) could be a lot extra obvious to people observing dwelling cells beneath a microscope (which in actual fact is the place a lot of the early analysis on H3O2 originated from). This in flip raises one other query: why are cells designed to create a lot liquid crystalline water?
Word: An extended article describing the lengthy historical past of analysis into liquid crystalline water (H3O2) and its bodily properties may be learn right here.
Mysteries of the Cell
Within the earlier article, I mentioned a standard challenge I observe inside science. When an incorrect mannequin is utilized to elucidate a pure course of, discrepancies between the mannequin’s predictions and actuality will inevitably seem.
One would count on that when this occurs, it will encourage these espousing the inaccurate mannequin to re-examine their mannequin, however as a substitute, since a lot has been invested into that mannequin, they as a substitute will denounce any challenges to it, and give you innumerable inventive methods to elucidate away every failure of the present mannequin.
Contemplate, for instance, the preliminary guarantees of the vaccines (in the event you get two doses, you had been advised that you’d be utterly immune, transmission would cease, and COVID-19 would quickly fade into reminiscence). For the reason that medical trials for the vaccines had been fraudulent, not one of the vaccines’ guarantees materialized, and the COVID state of affairs as a substitute grew to become worse.
Nonetheless, as a substitute of healthcare authorities (and the medical group) admitting their mistake and switching to a special method for managing COVID-19, they doubled down on the vaccine mandates and moved the purpose posts time and again with regard to what mass-vaccination (and boosting) was really supposed to perform.
Likewise, for mobile biology, our information of the cell is surprisingly primitive and the present fashions typically fail to elucidate what happens throughout the mobile atmosphere. Nonetheless, because the different fashions usually are not usually accepted by the scientific group, we’ve been pressured to repeatedly patch the present fashions in order that they’ll considerably account for the innumerable mysteries of life.
At this level, I imagine one of many key causes of this example is scientific analysis changing into distorted to prioritize specializing in discoveries that trade can revenue from.
For instance, immunology has a slim give attention to the features of the immune system which may be focused by vaccination or proprietary medicine, which in flip has left many different parts of the immune response uncared for (the immune system is often known as one of many least understood techniques within the physique).
Equally, since pharmaceutical medicine typically work by affecting receptors and channels in cells, mobile biology has adopted a narrow-minded give attention to simply these features of a cell.
In flip, the liquid crystalline part of water supplies quite a lot of explanations for most of the organic phenomena that the present fashions merely don’t adequately handle. On this article, I’ll focus upon just a few of them.
Word: A lot of what’s mentioned on this article is roofed in additional element inside these three books (equally, the vast majority of the references for this text are sourced from these books, so I can’t repetitively cite them all through the article). In the event you want to additional research the topic your self, I might suggest studying these books (all authored by Gerald H. Pollack) on this order:
- The Fourth Section of Water: Past Strong, Liquid, and Vapor (2013)
- Cells, Gels and the Engines of Life: A New, Unifying Strategy to Cell Operate (2001)
- Section Transitions in Cell Biology (2008) — that is probably the most technical of the three
Mobile Integrity
One of many main puzzles of biology is the immense sturdiness that cells have. In the event you take into account the basic mannequin — cells being luggage of liquid contained inside a fluid mosaic membrane, it must be easy for exterior forces to “pop” cells and have all of their contents spill out. But typically, cells keep their integrity regardless of vital stressors.
Cells can survive traumas, together with being guillotined in half, drawn and quartered (so particular parts may be remoted and labored with — comparable to when performing in vitro fertilization), or shot stuffed with holes with electrical bullets, every of which one would count on could be ample to “pop” them. Nonetheless, in every occasion, mobile integrity of the remaining part persists.
Equally, if the membrane from a cell is eliminated, its inner contents stay in place reasonably than quickly dispersing. It has additionally been recognized for over 50 years that if muscle fibers lose their membranes, their practical means (making a contractile power) stays intact.
Three clues assist to elucidate these phenomena. The primary is that — as Pollack has proven — water droplets have a exceptional quantity of integrity, and like cells, will keep their integrity (and subsequently fuse again collectively) if a micro-blade is used to guillotine them in half. The second is that Pollack has additionally proven water droplets include a big diploma of liquid crystalline water which possible is what confers their integrity.
The third is that the water molecules in cells predominantly exist inside gels, that are composed of that very same liquid crystalline water. Put in another way, which means that a cell’s stability is basically a property of its water holding it collectively reasonably than the exterior construction which encapsulates it.
One other necessary side of mobile structure ought to now be thought-about. Because the situations for liquid crystalline water formation are current all through the cell (negatively charged hydrophilic surfaces and ambient infrared vitality), the cells ought to quickly be filling themselves with liquid crystalline water layers lots of of micrometers in thickness.
But, all through the cells, the surfaces are sometimes solely fractions of a micrometer aside. Which means the construction of the cell relies upon upon the continuous formation of liquid crystalline water, however concurrently constrains that crystalline construction from rising to its full measurement.
Tensegrity
Classically in structure, buildings are created by having sturdy skeletons upon which the remainder of the construction rests. For instance, within the outdated days, we regularly used stone pillars; these days, skyscrapers require metal superstructures to fulfill the wants of those buildings:
This mannequin typically doesn’t work inside dwelling organisms, as a result of life, in contrast to these buildings, requires fast motion, and dwelling organisms merely can’t produce strong constructions with the identical energy as metal beams. Nonetheless, another and extra advanced architectural mannequin has been developed which is regularly utilized by those that embrace complexity inside their fashions.
Tensegrity (brief for tensional integrity), was a mannequin first put ahead by Buckminster Fuller. It posits that if a collection of non-compressible constructions are linked collectively by a lattice of elastic connections (which may retailer stress when stretched), a a lot stronger construction is created.
It is because any power the construction receives will probably be equally distributed via every of these elastic connections reasonably than concentrating on a single part (e.g., the stone pillar), and thus, a lot much less prone to exceed the breaking level of any single structural part.
Fuller’s work subsequently impressed quite a few buildings to be constructed on the ideas of tensegrity. It is a basic image of him holding a tensegrity sphere he made:
Biotensegrity encapsulates the belief that this similar system additionally happens all through nature. For the human physique, at every stage of group, a linked tensile matrix is current that confers its stability.
One French hand surgeon, Jean-Claude Guimberteau, has likewise achieved a exceptional job of demonstrating the presence of linked tensile constructions on the stage of fascia (a connective tissue current all through the physique many guide therapists work with), via small (magnified) cameras positioned within the physique throughout minimally invasive surgical procedures:
Word: On the magnification scale used right here and in his different movies, liquid crystalline water may be straight noticed coating these constructions. Additionally notice its lubricating high quality that enables the constructions to slip previous one another. Lack of this lubrication seems to create quite a lot of points throughout the physique.
Because the years go by, there seems to be a better consensus throughout the holistic medical subject that biotensegrity is a sound mannequin for understanding the physique, and that linked networks of stress are current from the most important to the smallest ranges of the physique (e.g., the cytoskeleton is the elastic connecting unit inside every cell). Nonetheless, whereas this concept is regularly mentioned, there are nonetheless two main unaddressed points with it, which I imagine liquid crystalline water can clarify.
The primary is that in Guimberteau’s work, he had noticed that tiny vacuoles (enclosed compartments full of water) all through the physique type the fundamental incompressible unit that a lot of the physique’s tensegrity relies upon upon.
The second is that at a good larger magnification inside cells, whereas a cytoskeleton is current that’s beneath stress, there’s nothing that may be seen which creates that stress (and it’s extremely debatable if the cell’s connections to the extracellular matrix suffice to create that stress). This issues as a result of the structural energy of a tensegrity system solely emerges when a construction’s parts are beneath stress.
Within the case of the previous, I imagine that the microvacuoles are full of liquid crystalline water (which can’t be compressed). Within the case of water droplets, Pollack concluded that the mutual repulsion between positively charged protons (pushed to the middle of the droplet by sheets of H3O2) creates an outwards power resisted by the liquid crystalline boundary of the droplet.
The stability between these two forces ends in the droplet assuming a spherical type, and I imagine the identical mechanism is at work within the microvacuoles all through the human physique.
Within the case of the latter, you will need to bear in mind how a lot growth is produced by proteins that create gels (many gels are over 99.9% water). Pollack, in flip, has proven that the liquid crystalline water that’s always making an attempt to type throughout the cell is unable to succeed in its full measurement on account of proteins resisting the stretch that must happen had been the liquid crystalline gel to develop to its full measurement.
This occurs each on the stage of the cell (because the cytoskeleton stretches because the cell expands to its most measurement, till it can’t permit additional growth to happen) and inside proteins all through the cell.
On the protein stage, the physique typically depends upon chemical bonds to be made between proteins to constrain the utmost growth that may happen in response to a gel forming. Moreover, proteins can alternate between a folded and an unfolded conformation (e.g., a helix vs. a coil), one thing typically decided by the strain utilized to the protein (such because the expansive stress of liquid crystalline water inside a gel).
There are a selection of significance penalties of this conformation change which will probably be mentioned later on this article (e.g., for the physiology of muscle tissue). Moreover, many different parts of the physique additionally seem to depend on liquid crystalline water:
“Finding out collagen, Melacini et al. famous the significance of water in stabilizing its triple helix crystalline construction. They discovered that water throughout the collagen helix varieties a “semi-clathrate-like construction that surrounds and interconnects triple helices within the crystal lattice.”
Water throughout the matrix of bone is likewise extremely structured, a structuring that has been discovered related not solely with natural macromolecules comparable to collagen and proteoglycans, however with the mineral surfaces as nicely. Water, in actual fact, appears to play a foundational function in orienting mineral nanoparticles into parallel preparations throughout the bone matrix, offering this orientation even within the absence of natural molecules.”
On a regular basis Gel Expansions
Many applied sciences we’re acquainted with (e.g., diapers) depend on hydrogels which may increase right into a semisolid construction which retain water. Equally, we will straight observe that many bigger processes throughout the physique are additionally dependent upon water’s tendency to assemble into the bigger liquid crystalline constructions.
As a result of the conventional structure of protein’s cross-linking habits limits how a lot gels can increase (because the proteins which would want to separate to accommodate the rising gel are prevented from doing so by cross hyperlinks between them), when tissue or protein is broken, this limitation may be partially eliminated. Consequently, it may be seen on a microscopic scale that human tissue will swell and increase when it’s broken.
Likewise, Pollack has argued that that is more than likely what occurs once you expertise a musculoskeletal trauma. In Pollack’s proposed mannequin, the preliminary gel formation additional expands the present tear, and this progressive growth of liquid crystalline water ultimately results in seen swelling.
On a bigger scale, one of many main engineering challenges for the physique is having weight-bearing joints just like the knees be capable to keep their vary of movement with out changing into broken by the continuous friction they expertise each day.
A exceptional attribute about liquid crystalline water is that, supplied the floor from which it varieties stays intact, liquid crystalline water may be destroyed after which reform, together with its virtually frictionless floor, over and over.
Due to this, the liquid crystalline water finally ends up being the part which absorbs the stress skilled by wholesome joints, and supplied the joint is wholesome, this water can immediately regenerate from that stress. Along with this regenerating layer of negatively charged liquid crystalline water, on the very heart of the joint, there’s a pocket of positively charged protons which repel from one another and create an expansive stress (like what’s seen in a water droplet).
For the reason that joint capsule seals this area, these protons are unable to flee and thus successfully perform like repelling magnets (e.g., take into account a maglev practice) that resist the load of the physique and keep the central area throughout the joint.
One of many issues I take into account probably the most compelling about Pollack’s mannequin for the joints is the particular high quality of synovial fluid contained in the knee joint. Whenever you view it on a digicam throughout an arthroscopic surgical procedure, diffusion inside it’s visibly slowed, whereas in the event you straight extract it (e.g., throughout a knee aspiration), you’ll be able to inform that it has a a lot thicker and gelatinous high quality, one thing I’ve discovered to affiliate with the presence of liquid crystalline water.
Pollack likewise argues that his mannequin suggests EZ (liquid crystalline) water’s habits resembles that of a gelatinous egg white which is semisolid when left alone, but in a position to circulate in response to an imposed shear power.
Mobile Gradients
Word: A “gradient” describes a distinction within the focus of issues in two completely different areas. This might embrace electrical fees (i.e. batteries rely upon gradients), electrolytes, or temperatures — and plenty of gradients present an simply harvestable supply of vitality.
The prevailing paradigm of physics asserts the next:
- The pure state of issues is to be disordered and evenly combined.
- Anytime you make one thing grow to be extra ordered (e.g., forming a crystal or making a gradient between two areas), vitality should be expended to create that ordering.
- When an ordered construction turns into disordered, vitality is launched within the course of which may generally be harvested (e.g., combusting wooden in a wooden range to warmth our properties).
- Anytime vitality is launched from one thing, in the event you try and seize and retailer that vitality, some vitality will at all times be misplaced.
These legal guidelines, in flip, are used to refute the chance that any sort of “free-energy” system can exist, such because the exclusion zone (EZ) water system Pollack has proposed the place quite a few harvestable gradients are created. Sadly for the present paradigm, biology typically seems to violate these legal guidelines, as it’s regularly transferring in direction of a extra ordered state reasonably than the disordered state the present paradigm predicts.
The present decision for this paradox (which gained a Nobel prize) is that dwelling organisms perform as “dissipative constructions,” which trade the order in giant quantities of ordered parts they accumulate from their atmosphere in return for imparting order to their very own disordered contents.
Though to some extent this permits the present paradigm to maintain itself, I don’t imagine it’s totally correct as water, via its liquid crystalline construction, has the flexibility to retailer radiant vitality that passes via it and convert that vitality to order the physique can then make the most of.
The Sodium Potassium Gradient
One of many issues dwelling cells are well-known for doing is concentrating potassium inside themselves and reciprocally expelling sodium. For the reason that focus inside and outdoors cells differs, a gradient exists, which, by the present legal guidelines of physics ought to attempt to equalize itself and quickly disappear.
Since this doesn’t occur, the present mannequin has argued that the mobile membrane prevents the passage of most however not all sodium and potassium (thereby inhibiting the gradient from equalizing itself) and that sodium potassium pumps on the mobile membrane exist which continuous swap sodium contained in the cell for potassium exterior the cell.
As a result of this trade is so very important to sustaining the well being of the cell, a big focus in mobile biology is positioned on the significance of the sodium potassium trade pump. Sadly, there are three elementary issues with this mannequin (the proof of every of those and extra is introduced by Gilbert Ling right here):
- The maths doesn’t add up — the present sodium potassium pumps merely shouldn’t have the capability to counteract the pure undoing of the sodium and potassium gradients. For instance, in muscle cells, sustaining the sodium potassium gradient with pumps requires between 4 to 30 occasions the complete accessible vitality within the cell.
- Cells are in a position to keep a gradient with quite a lot of different undesirable parts they expel (e.g., micro organism expelling antibiotics) and to elucidate these phenomena, an increasing number of pumps are recognized to attempt to assist the mannequin. It is a drawback as a result of it’s unlikely that cells have the capability to concurrently maintain so many alternative pumps.
- Ling took frog muscle cells whose atmosphere was altered in order that they had been utterly starved of vitality (which is required to function the sodium potassium pump). Regardless of this, the gradient was maintained.
This then begs the query of what might be creating this gradient? Ling made the next observations:
- The gradient was maintained if the cell membrane (the place these pumps reside) was eliminated.
- Producing a membrane with sodium potassium pumps that didn’t include a cytoplasm (the within of a cell) resulted within the gradient quickly disappearing from with the membrane.
This means that the gradient is a property of the cell cytoplasm reasonably than the mobile membrane. Apparently, the similar property has been present in synthetic gels, which just like the cytoplasm, additionally generate giant quantities of liquid crystalline water:
“We present that the gel barrier is ready to keep a secure separation of ionic options of various ionic strengths and chemical compositions with none pumping exercise. For the Na+ /Okay+ focus gradient sustained throughout the barrier, a damaging electrical potential develops throughout the Okay+ -rich aspect. The state of affairs is harking back to that within the cell.
Moreover, additionally the advective circulate of water molecules throughout the gel barrier is restricted, regardless of the gel’s giant pores and the osmotic or hydrostatic stress gradients throughout it.”
This focus phenomenon has additionally been noticed by different authors:
“Proof for such accumulative condensation was produced virtually a century in the past when Bungenberg de Jong in 1932 confirmed that even dilute options of polymers, when shaken, coalesced into droplets-then referred to as coascervates-in which the natural matter grew to become extremely concentrated. The polymer focus in such droplets might exceed the focus within the surrounding bathtub by as a lot as 10,000 occasions.
When positioned in sure dyes, the droplets grew to become progressively extra coloured, the depth typically many occasions exceeding that of the encompassing answer. Thus, gel droplets had the capability to pay attention sure solutes, because the cell concentrates potassium.”
Since gels independently display most of the inexplicable traits of cells, it’s thus affordable to conclude they may share a mechanism for producing the sodium potassium gradient noticed all through biology.
Boundaries
One main problem for all cells is protecting undesirable issues out. Classically, we view the method of pathogenic substances coming into cells as being a product of their interplay with matching receptors on the cells (a world view which I imagine is emphasised by medical science as a result of medicine may be developed to disrupt this course of). I, in flip, imagine that this exclusion course of by the cell is closely influenced by current fees, zeta potential and liquid crystalline water.
As a result of liquid crystalline water can for probably the most half solely type on negatively charged surfaces (the identical manner that water molecules every expel half a hydrogen atom and thereby maintain a web damaging cost as a result of misplaced hydrogens), virtually each floor within the physique (and plenty of different pure techniques) is coated with a damaging cost.
Since colloidal stability (which governs the habits of most fluid techniques) largely relies upon upon the mutual repulsion created by similar fees, most pure colloidal techniques make the most of damaging fees to stay dispersed and solely clump collectively if extreme constructive fees are current (likewise most strategies of restoring zeta potential function on this precept).
Pathogenic organisms typically impart constructive fees to their atmosphere (comparable to via micro organism decarboxylating the damaging fees of amino acids inside proteins). This causes proteins and cells contained in the physique to start clumping collectively (the malaria parasite is especially good at doing this), which each prevents the immune system from getting access to the microbes and will increase the microbe’s means to achieve entry to the cells.
One of many notably fascinating observations made by the unique proponent of physiologic zeta potential was that bacterial and viral infections (I imagine this was probably the most studied with influenza) would create a constant degradation of the physiologic zeta potential. This supplies an evidence for why viruses like influenza may be a lot extra harmful for the aged.
Somebody with a wholesome zeta potential can tolerate a minor impairment of their colloidal stability (they may simply really feel a bit unwell), however for somebody who already has an impaired zeta potential (which is a quite common consequence of getting old), that discount may be ample to go a essential threshold the place extreme sickness onsets.
One of many earliest distinguishing traits of COVID-19 to me was that many sufferers developed medical indicators suggesting extreme zeta potential disruption, one thing I had not seen with every other respiratory virus. A key purpose I used to be involved in regards to the spike protein lengthy earlier than the vaccines entered the market, was as a result of I had recognized it because the possible offender for this zeta potential disruption.
This was on account of it being a novel part of the SARS-CoV-2 virus (it differed from that of SARS-CoV-1) that was current on the floor of the virus and which had an unusually excessive constructive cost density. It has since been proven that the spike protein straight induces clumping of pink blood cells, possible on account of its cost distribution having the potential to create a big disruption of physiologic zeta potential.
One of many fascinating feedback I’ve repeatedly seen acknowledged by each people who’ve taken protocols to enhance their physique’s manufacturing of liquid crystalline water and people who’ve achieved the identical for enhancing their zeta potential, is that they not often get sick.
This might probably imply both that the signs of infections are rather more minor if these physiologic parameters are already in good well being (e.g., because you don’t go a essential zeta potential threshold), or as a result of they straight stop cells from changing into contaminated by pathogens.
As many components which positively have an effect on one of many parameters typically have an effect on the opposite (e.g., earthing improves zeta potential and promotes the expansion of liquid crystalline water within the physique), it’s a bit onerous to say which impact in the end predominates, and an ideal deal of my analysis on this matter was based mostly on making an attempt to reply that query.
Word: The strategies of restoring zeta potential and rising liquid crystalline water throughout the physique are mentioned additional right here.
On this article, we assessment a few of the proof supporting that barrier speculation. The earliest I got here throughout was from the work of Viktor Schauberger (1885-1958), who believed it was critically necessary for water to journey in a vortexing sample, one thing as mentioned within the earlier a part of this collection, has been proven to extend the presence of liquid crystalline water.
One of many many discoveries made by using vortexing techniques based mostly on his design for water provides was that it lowered the expansion of micro organism throughout the water system (e.g., on the within of pipes).
Different analysis has straight discovered that the presence of liquid crystalline water prevents the expansion and invasion of micro organism, comparable to this research:
“In a take a look at carried out with E. coli, cells progressively penetrated EZ [liquid crystalline water] over 2 days. Moreover, EZ-bearing Nafion had 80% much less biomass accumulation of E. coli over 2 days in comparison with an EZ-less, hydrophilic, clean aluminum oxide floor. This means that EZ might signify the primary line of protection, spatially and temporally, towards micro organism approaching sure hydrophilic surfaces.
These findings might have necessary implications in creating biofouling-resistant materials surfaces for purposes delicate to bacterial attachment and biofilm formation.”
And this research:
“Silk sericin is a globular protein whose resistance towards fouling is necessary for purposes in biomaterials and water-purification membranes. Right here it’s proven how sericin generates a water-exclusion [liquid crystalline] zone which will facilitate antifouling habits. Negatively charged microspheres had been used to imitate the floor cost and hydrophobic domains in micro organism.
Immersed in water, sericin fashioned a 100-µm-sized exclusion zone (for micron-size foulants), together with a proton gradient with a lower of >2 pH-units. Thus, when involved with sericin, water molecules close to the floor restructure to type a bodily exclusionary barrier which may stop biofouling.
The decreased pH turns the aqueous medium unviable for neutrophilic micro organism. Due to this fact, resistance to biofouling appears explainable, amongst different components, on the premise of water-exclusionary phenomena.”
Many tissues rely on the presence of liquid crystalline water lining them, and that is possible at the least partly, as a result of protecting barrier they create. Inexperienced and Otori in 1970, for instance, discovered exclusion zones roughly 350 μm deep extending from the cornea, and in addition from contact lenses (it’s necessary to guard the attention from injury, and liquid crystalline water features as a clear, well-lubricated barrier, qualities each essential for the eyes).
Pollack, roughly 15 years in the past, additionally discovered similar outcomes (the presence of liquid crystalline water) subsequent to polyNIPAM, the gel used to manufacture contact lenses.
One of the crucial necessary tissues within the physique for offering a protecting (however well-lubricated layer) is on the endothelial lining of the blood vessels. There, giant quantities of blood creating vital shear forces always go over the blood vessels. Thus far, Malcom Kendrick has famous that the areas of circulation which expertise the best shear forces are the more than likely to develop the continual injury which ultimately results in coronary heart illness.
The protecting coating of the endothelium, the glycocalyx, is structured (on account of its excessive sulfate content material) to create giant quantities of gel (liquid crystalline water) round it and thus shield the endothelium. Moreover, a skinny layer that blood cells can’t enter is understood to straight line the partitions of even the smallest blood vessels.
Equally, researchers in 2000 noticed a 0.4-0.5μm thick gelled layer of water lining the endothelium of wholesome capillaries (the smallest blood vessels within the physique), and this lining excludes quite a lot of completely different substances from reaching the endothelium.
Formally, the vaccine spike protein can’t have an effect on the endothelium as a result of it lacks a practical ACE2 binding area (whereas the COVID-19 virus has a practical one via which it then enters the cell).
Though that is the case, there are many different methods that the spike protein can nonetheless connect to the endothelium (e.g., the spike protein can nonetheless connect to the receptor, it straight binds heparin within the glyocalyx, and whether it is produced from contained in the endothelium by the vaccine, it has successfully entered the endothelium).
Since autopsies of people suspected to have died on account of vaccination have revealed profound injury to the endothelial layer, this supplies sturdy proof that the spike protein in a method or one other has the flexibility to penetrate the usually protecting barrier there.
Many have suspected that that is partly as a result of extremely constructive cost that the spike protein (and the generally positively charged parts of the lipid nanoparticles) carries, as these constructive fees can penetrate the liquid crystalline water barrier defending cells just like the endothelium.
I imagine it might even be as a result of spike protein’s disruption of zeta potential, as different states related to elevated blood viscosity (e.g., uncontrolled diabetes) are recognized to injury the endothelium and speed up the development to heart problems.
Section Transitions
Though liquid crystalline water is critical for all times, an excessive amount of of it can be problematic. For instance, if the complete cell was coated with gel-state water, it will not be attainable for a lot of issues that wanted to enter the cell to enter.
To resolve this drawback, areas of constructive cost exist within the membrane (e.g., Pollack argues that this can be a key purpose for the location of steel ions throughout the cell membrane), which stop liquid crystalline water from forming over the world and thus create an open passage for water to journey via.
Word: Though we’re taught to think about the cell as a fluid mosaic of phospholipids with proteins right here and there, roughly 50% of the cell membrane is often composed of proteins (and it might probably generally be much more).
Most often, nevertheless, the physique depends upon with the ability to remodel water between its gel (liquid crystalline) state and a sol (bulk water containing colloidal suspensions) state as wanted. Nonetheless, whereas recognition of the elemental significance of part modifications in mobile biology has step by step elevated during the last 70 years, the vast majority of the scientific subject continues to be wedded to the fluid mosaic speculation, which believes that the mobile membrane is at all times a liquid.
Briefly, gels (each pure and artificial ones) usually have a temperature (its transition level) the place the gel will endure a fast transition from one state to the opposite (defined additional right here). So far as I do know, in all instances, the warmer temperature will correspond to the sol state (H2O water with suspended colloids) and the colder one will correspond to the gel state (H3O2). Moreover, elevated stress will even promote the gel state:
“Organic exercise virtually universally requires that membranes be of their fluid state; in lots of instances, simply above the transition level.”
Gels all through the physique, in flip, are designed to have a part transition level close to the conventional temperature of the physique. This will likely clarify why most mammals and birds keep their temperature between 35°– 42°C (95°– 107.6°F; the conventional temperature for people is 37°C or 98.6°F), an in any other case curious truth given how a lot their our bodies and environments differ (e.g., a tiny fowl within the desert vs. a blue whale).
Moreover, this temperature extends past warm-blooded animals. A tuna fish, when lively, maintains the temperature of its physique at 30°C or 86°F (the ocean is way colder) whereas many reptiles keep their physique temperature close to 40°C or 104°F (by doing issues like searching for out the solar). Many bugs additionally can’t fly till they’ve warmed as much as an analogous vary of temperature (e.g., 38°C or 100.4°F for bumblebees).
Equally, the part transition level is closely influenced by the supplies that the gel builds from (e.g., parts of the cell membrane). Chilly-blooded animals in flip have been noticed to vary the composition of their cell membranes in response to their atmosphere.
In a single experiment, Calotes versicolor (the frequent backyard lizard), had been acclimatized to 16°, 26°, and 36°C (60.8°, 78.8°, and 96.8°F) for a interval of thirty days. The lizards exhibited dramatic modifications within the focus of main phospholipids (parts of the cell membrane) comparable to phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, cardiolipin, and sphingomyelin.
Temperature acclimatization has additionally been noticed to range the lipid composition of carp muscle microsomes together with carp blood cells, and seasonal variation has been noticed within the lipid composition of brains of rainbow trout.
As soon as the gel is held close to its transition temperature, it’s then relative straightforward to vary precisely the place that transition temperature is so water may be stored within the applicable part for the present physiologic wants. That is primarily achieved throughout the physique by altering the electrolyte composition of the world, as sturdy cations (positively charged ions) destroy gels, whereas sturdy anions (negatively charged ions) reinforce them.
So far as I can inform, the results of those ions correlate to the excessive valence (cost) anions (-) that the majority successfully assist physiologic zeta potential and people excessive valence cations (+) which most successfully destroy it.
The first cation factor which the physique makes use of to shift the transition temperature with the intention to destroy gels is calcium (Ca). As an instance the impact of calcium graphically (notice how a sudden essential threshold of Ca focus is reached):
These outcomes additionally confirmed how the upper valence cations, Ca2+, trigger smaller gels to type relative to low valence cations Na(1)+.
As soon as you place all of this collectively, you successfully get a state of affairs like this throughout the cells which permits small secretions of calcium there to shift its water from a fluid to a gel state.
Conversely, if the physique can disperse the gels, it additionally wants a solution to recreate them. The first sturdy (excessive valence) anion it makes use of to construct them are the phosphates in adenosine triphosphate (ATP).
After we take into account this different perform of ATP, we must always take into account a few of the concepts first proposed by Ling (see 8.4 on web page 178). They counsel that a lot of the vitality obtained from ATP arises not from the vitality inside its bonds being damaged, however reasonably from it inducing water to type a liquid crystalline construction. In essence, a lot of the vitality generated from ATP in the end arises from the radiant vitality which triggers these polymerizations (gels).
Section transitions are quite common in mobile biology, and whereas the sector doesn’t place a heavy emphasis on their significance, Pollack’s central argument in his first two books is that part transitions are mandatory to elucidate many features of the cell.
Word: Once I later mentioned my articles with Pollack, he knowledgeable me that the primary oversight together with his earlier analysis was that that they didn’t but know that the gels had been negatively charged, which in flip explains quite a lot of the results they create (e.g., {the electrical} impulse of nerves).
Increasing Gels
One of many main makes use of for gels throughout the physique is from them to quickly increase and create results from that growth. For instance, cells regularly excrete small spheres (referred to as vesicles) containing necessary parts, which upon exiting the cell quickly increase. Remoted mucin-producing vessels for instance endure a 600 fold growth in 40 milliseconds.
Previous to exiting the cell, the interior parts of the vesicle are cross linked collectively by Ca2+ (bear in mind, larger valence cations, via crosslinking gel proteins, will restrict gel formation whereas monovalent cations like sodium as a substitute are likely to increase them).
As soon as secreted from the cell, Ca2+ is eliminated and the gel quickly hydrates within the Na(1)+ answer surrounding every cell. Conversely, gels is not going to quickly increase in distilled water, and it has been noticed that liquid crystalline water’s formation can also be diminished inside deionized water.
Word: Some vesicles make the most of native environmental components to vary their part. For instance, histamine is a monovalent cation (cost of +1) at a impartial pH, however turns into a divalent cation (cost of +2) in an acidic pH. Researchers had been in a position to present that histamine in an acidic atmosphere (on account of its excessive valence state), causes shrinking of mast cell granules, whereas histamine in a impartial atmosphere permits their growth.
Muscle Physiology
Most of the commonest issues for which sufferers hunt down physicians originate from the muscle tissue. Due to this, I’ve checked out numerous alternative ways to deal with these points. In flip, I’ve discovered fairly just a few that constantly work however I can’t clarify why as the present mannequin of muscle physiology can’t present an evidence.
One of many main issues with drugs (and sometimes science) is what I time period the “mechanistic lure.” Briefly it implies that if there’s not a mechanism to elucidate why one thing works, then it’s assumed to be a hoax and thought to not really work. I believe this compulsive want for a mannequin is sort of silly, particularly since most of the fashions we make the most of to elucidate why medicine work, don’t really make sense.
Equally, there are numerous instances of a beforehand accepted mannequin for a drug’s mechanism that was discarded and changed with one other, and I do know of many extra examples the place an unorthodox mannequin seems to offer a significantly better rationalization for the mechanism of a remedy.
Word: This additionally holds true for a lot of different non-drug therapies.
Sadly, it’s practically not possible to have the FDA (or many conventionally skilled physicians) be open to contemplating a remedy for analysis until a biochemical mechanism for it’s proposed. I imagine this can be a reflection of the actual fact pharmaceutical medicine, as they’re designed to focus on sure enzymes within the physique, match into our inflexible mechanistic paradigm, whereas therapies with a broad spectrum of motion can’t be linked to a selected biochemical receptor nor as simply profited from.
Given all of this, I used to be overjoyed to find via Pollack that many features of the present mannequin for muscle physiology don’t make sense, and the anticipated outcomes of the mannequin don’t happen when rigorous experiments on muscle tissue are carried out:
Nonetheless, another mannequin for muscle physiology additionally exists. As we take into account it, we must always remember that muscle tissue are acknowledged to solely be able to contracting. Within the situations the place one thing within the physique wants to elongate, that is achieved by having a muscle in the proper place shorten, and on account of its place, create a lengthening someplace else via doing so (e.g., the triceps within the arm).
From Pollack’s work, I spotted that whereas muscle tissue can solely create power throughout a contraction, that is really a results of the actual fact their parts can solely forcefully lengthen.
Pollack’s mannequin is predicated on the remark that relaxed muscle tissue include a considerable amount of structured water, whereas contracting muscle tissue primarily include water not in a semisolid gel state. Since it’s recognized that muscle firing follows the nerve sign directing calcium (Ca2+) ions to enter the muscle, this implies a calcium induced part change might underlie the method.
Conversely, additionally it is recognized (from the experiment beforehand described within the gradient part) that whereas muscle cells which have been reduce open can retain their potassium to sodium gradient whereas in a salt answer, the elements that lack ATP are unable to.
This means that ATP is critical for the liquid crystalline state of water to be current, because it excludes sodium ions from coming into the muscle cells. Equally, additionally it is recognized that with out ATP, muscle tissue will stay caught within the contracted type and be unable to elongate, one thing that happens shortly after demise (termed “rigor mortis”).
Word: One of many compelling anecdotal tales I’ve heard over time is that when severely vaccine-injured kids die (e.g., these with lifelong debilitating autism) rigor mortis units in a lot quicker for them. Those that noticed this recommended that these kids had a continual vitality deficit, and their our bodies had been struggling to make sufficient ATP to get by. I believe that is very attainable, nevertheless it may be indicative of poor zeta potential.
I believe this may additionally be seen with different continual debilitating sicknesses, however I’ve not interacted with the individuals who would have noticed if it did in actual fact happen.
Pollack additionally noticed that muscle modifications in response to environmental components adopted a well-known essential threshold being handed. This additionally appeared to counsel to Pollack {that a} part change was occurring throughout the muscle tissue.
So what’s Pollack’s mannequin? The muscle tissue fibers are designed to type giant gels round them, and as liquid crystalline water inside them expands, it stretches the uncoiled proteins within the fibers into helixes (till protein cross hyperlinks stop additional stretching). When the muscle must contract, calcium ions enter the muscle, eliminating the gels, and the proteins now not being lengthened elastically snap again to their unique uncoiled configuration.
To ensure that the gel to rebuild, ATP is required to interrupt the cross hyperlinks created by calcium and thereby set off a part shift that reconstructs the gel.
Thus, the energy of a muscle is a product of the potential vitality created by liquid crystalline water’s storage of radiant vitality being launched. Or put in another way, the energy of muscle tissue really lies of their means to spontaneously lengthen and explains why many efficient muscular therapies I’ve come throughout work.
Massive mechanical shear causes the cytoskeleton matrix [another key structure that expands and contracts in response to phase changes] to fluidize, a phenomenon just like bodily rejuvenation in SGM’s [certain synthetic materials]. This fluidization is adopted by a sluggish scale- free restoration of mechanical properties, a phenomenon just like bodily getting old in SGMs.
Surprisingly in response to a transient stretch, the cytoskeleton fluidizes in a sample that’s common for various cell sorts. This discovering implicates mechanisms mediated not a lot by particular signaling pathways, as it’s normally assumed, however reasonably – as we clarify beneath – by non-specific actions of bodily forces.
Many different constructions even have the flexibility for his or her inner gels to trigger growth and contraction, however in contrast to skeletal muscle tissue, typically, this growth and contraction just isn’t as tightly constrained as what’s noticed throughout the closely cross-linked skeletal muscle tissue.
Clean muscle tissue, in addition to contractile rings, artificial actin gels (actin is among the commonest contractile proteins within the physique), and different organelles with few covalent cross hyperlinks and semi-random constructions are different examples of locations the place the physique makes use of this precept to maintain life.
Lastly, it has additionally been noticed that altering the encompassing concentrations of salinity round different fibers (e.g., collagen) could cause them to increase and contract to the purpose they’ll generate a power yielding contraction just like that of a muscle fiber.
Conclusion
There have been just a few central questions I’ve sought to handle in my exploration of liquid crystalline water. On this collection, I sought a mechanism to elucidate the remark in quite a few conventional medical techniques that an inherent expansive power exists all through the physique which performs a key function in offering its vitality and that when this expansive power is compromised, quite a lot of ailments set in.
I agree with this perception and have seen quite a few situations the place it grew to become attainable to acknowledge the place that life sustaining growth had been changed with a good compacted area, and likewise seen strategies that sought to revive that growth additionally restore a affected person’s vitality.
Conversely, I imagine the lack of mobility and sturdiness that accompanies getting old (and one of many greatest considerations to elder sufferers) is straight associated to the lack of liquid crystalline water we usually expertise with age.
On this article, I’ve tried as an example the structural results of liquid crystalline water throughout the physique, and it’s my hope that via doing so, I’ve supplied a mechanism to elucidate the place that expansive power originates from. Within the subsequent a part of this collection, I clarify how water’s liquid crystalline state creates a gradient that may be harvested for vitality and creates the circulation life relies upon upon.
Within the article after that, I did my finest to elucidate the intertwined relationship between liquid crystalline water and zeta potential, and within the last a part of this collection I mentioned the strategies I’ve come throughout which seem to revive both.
Every of those matters is sort of advanced (e.g., this text was a synthesis of quite a few books and articles), however in my view nonetheless essential to dive into for unravelling the mysteries of life. In flip, it’s my honest hope the widespread awakening that has occurred in our society because of COVID-19 can rekindle curiosity to discover unconventional topics like this.
I thank every of you for the eye you gave in making an attempt to understanding this comparatively advanced matter which is close to and expensive to my coronary heart. I sincerely hope that you can also undertake a few of its implications into your each day life.
A Word From Dr. Mercola Concerning the Writer
A Midwestern Physician (AMD) is a board-certified doctor within the Midwest and a longtime reader of Mercola.com. I respect his distinctive perception on a variety of matters and I am grateful to share them. I additionally respect his want to stay nameless as he’s nonetheless on the entrance strains treating sufferers. To search out extra of AMD’s work, you’ll want to try The Forgotten Facet of Medication on Substack.
